Diablo IV Endgame Farming Guide: How to Turn Divine Gifts Into Mythic Uniques

Diablo IV’s endgame is defined by efficiency. Once you’ve pushed your character into the highest World Tiers and established a functional build, raw power no longer comes from leveling alone—it comes from understanding systems, exploiting farming loops, and stacking mechanics that multiply your rewards. One of the most overlooked yet powerful systems introduced through seasonal content is the Divine Gifts mechanic, specifically the Essence of Sin and Essence of Hellfire granted by Asmodan.

When used correctly, these Divine Gifts form the backbone of a self-sustaining boss-farming loop that can reliably generate boss materials, Diablo 4 Gold, and ultimately Mythic Unique items. This guide breaks down the entire process step by step, explaining not just what to farm, but why each step matters and how it all connects into one efficient cycle.

Understanding Divine Gifts: Essence of Sin and Essence of Hellfire

Divine Gifts—also referred to as seasonal powers—are progression-based enhancements tied to the Asmodan seasonal system. The two most important gifts for endgame farming are:

Essence of Sin

Essence of Hellfire

These essences directly affect boss chest rewards and material drops, making them mandatory for any serious endgame player.

Recommended Levels

Ideally, you want Rank 5 in both Essence of Sin and Essence of Hellfire. If that isn’t immediately possible, Rank 4 is the minimum viable breakpoint. The power difference between Rank 3 and Rank 4 is substantial, while Rank 5 significantly boosts consistency and volume of drops.

To fully max both essences to Rank 5, you need 1,500 total experience across the two Divine Gifts.

How to Level Divine Gifts Efficiently

There are two main methods to gain Divine Gift experience, and both are viable depending on your build strength and available playtime.

Method 1: Farming Asmodan on Normal Difficulty

This is the most consistent method.

Killing Asmodan on Normal difficulty grants 5 experience to both Essence of Sin and Essence of Hellfire per kill.

Normal difficulty is preferred because kill times are much faster, allowing you to chain runs efficiently.

This method is repetitive but reliable, especially for players who want predictable progress.

Method 2: Hunting Red Burning Mobs

While exploring the open world, you’ll occasionally encounter red burning mobs.

Each red burning mob grants 1 experience to one of your essences.

This method is slower and less consistent but can supplement Asmodan farming.

Best used when multitasking or filling downtime between other activities.

While leveling these Divine Gifts is a time investment, it is absolutely worth it. Once completed, the payoff is massive in terms of materials, boss efficiency, and Mythic Unique acquisition.

Slotting Essences Correctly (First Configuration)

After leveling your Divine Gifts, your first critical setup is as follows:

Essence of Hellfire → Purified Slot

Essence of Sin → Corrupted Slot

This configuration is essential for the next phase of the farm, as it directly impacts boss material drops and chest rewards.

Farming Living Steel: Your Starting Capital

Before entering the self-sustaining loop, you need an initial stockpile of materials.

Your goal is to farm approximately 200 Living Steel from Helltide chests.

Important notes:

You only need to do this once.

This Living Steel acts as seed capital.

If you follow the loop correctly, you will rarely need to farm Helltides again.

Once you have this Living Steel, the system begins feeding itself.

Grigoire Farming: Stygian Stones and Shards of Agony

With your Living Steel stockpile ready, your next step is to farm Grigoire.

Why Grigoire Matters

Each Grigoire kill:

Consumes Living Steel

Drops Stygian Stones

Drops Shards of Agony

These items are essential for summoning Duriel later in the loop.

Bonus Encounters: Bile

While farming Grigoire, you may be ambushed by Bile.

This is extremely beneficial because Bile can drop:

Corrupted Eyes

Betrayer’s Husks

Both of these items are critical for later chest openings, so never skip these encounters.

Your immediate goal during this phase is to accumulate as many Stygian Stones as possible.

Converting Stygian Stones Into Shards of Agony

Once you’ve farmed Grigoire extensively, convert your Stygian Stones into Shards of Agony.

These shards are required to open Duriel’s chests, which are a cornerstone of this entire farming loop.

Duriel Farming: Corrupted Horns and High-Value Drops

Now it’s time to farm Duriel.

Use all of your Shards of Agony to summon Duriel and open his chests.

Key Drops From Duriel

Your primary target here is:

Corrupted Horns of Duriel

These will be used later to open specific boss chests tied to Tributes of Ascendance.

Duriel encounters can also trigger surprise attacks from Bile, which may drop:

Corrupted Eyes

Betrayer’s Husks

Again, these are extremely valuable and should always be collected.

Use all your Shards of Agony during this phase. Do not save them—you want to convert them fully into Corrupted Horns.

Cleaning Up: Bile Farming (If Needed)

After finishing your Duriel runs, check your inventory.

If you have Betrayer’s Husks, your next step is to actively hunt Bile and fight him directly.

The goal here is to convert Betrayer’s Husks into:

Corrupted Eyes of Bile

You’ll need these corrupted eyes for the next major phase of the loop.

Slotting Essences Correctly (Second Configuration – Critical Step)

Before moving forward, you must change your Divine Gift slots.

This step is absolutely critical.

Essence of Sin → Purified Slot

Essence of Hellfire → Corrupted Slot

Failing to swap these will dramatically reduce your rewards in the next phase. Double-check your seasonal interface before proceeding.

Farming Outdoor Asodan in Hawezar

Now comes the payoff.

Head to Hawezar, just south of Zarbinzet, and locate the outdoor Asodan boss (not Asmodan).

Kill Asodan and prepare to open two special chests:

Duriel Chest – opened using Corrupted Horns of Duriel

Bile Chest – opened using Corrupted Eyes of Bile

Why These Chests Matter

These chests are the heart of the entire farming strategy.

Important Loot Includes:

Living Steel

Exquisite Blood

Nightmare Dungeon Sigils

Tributes of Ascendance

The Living Steel and Exquisite Blood replenish your resources, ensuring the loop remains self-sustaining.

Nightmare Sigils can occasionally roll into extremely rare variants, including the Mythic Prankster Sigil, though this is not your primary focus.

Tributes of Ascendance: Your Path to Mythic Uniques

The true reason for this entire process is the Tribute of Ascendance.

Both Duriel’s Chest and Bile’s Chest have a chance to drop Tributes of Ascendance. If your Divine Gifts are leveled high enough—especially at Rank 5—it is very common to receive multiple tributes from a single chest.

These tributes are the most reliable source of Mythic Unique items in Diablo IV’s current endgame. While other methods exist, none offer the same level of consistency, volume, and control.

Unlike the Mythic Prankster Nightmare Sigil, which is extremely rare, Tributes of Ascendance are farmable, repeatable, and scalable with proper preparation.

The Self-Sustaining Loop Explained

Once fully operational, the loop looks like this:

Living Steel → Grigoire

Grigoire → Stygian Stones & Shards of Agony

Shards of Agony → Duriel

Duriel → Corrupted Horns + Bile materials

Outdoor Asodan → Living Steel, Exquisite Blood, Tributes

Repeat indefinitely

As long as your Divine Gifts are properly leveled and slotted, the system feeds itself.

Final Thoughts

Diablo IV’s endgame rewards players who think strategically rather than grind blindly. By leveraging Divine Gifts, boss mechanics, and chest reward modifiers buy Diablo 4 Gold, you can turn what looks like a long farming process into a powerful, efficient loop that consistently generates Mythic Unique items.

While the setup requires time and attention to detail, the payoff is immense. Once established, this method minimizes Helltide farming, maximizes boss efficiency, and transforms Tributes of Ascendance into your primary progression tool.

If you’re serious about pushing Diablo IV’s endgame to its limits, mastering this Divine Gift farming loop is not optional—it’s essential.